How to be efficient and environmentally-friendly at the same time: solid-state routes to materials and molecules

 

 

Tomislav Friščić

 

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom; E-mail: tf253@cam.ac.uk

 

 

There is a global need for chemical transformations which are environmentally-friendly, while in the same time efficient in terms of energy and material usage, as well waste production. This need can be adequately addressed through developing synthetic approaches based on solid-state reactivity. This contribution will delineate the recent advances and advantages of mechanochemical reactions (i.e. reactions induced by mechanical force) in the context of organic,1 metal-organic2 and supramolecular synthesis.3

 

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Particular topics to be addressed include the thermodynamic equilibrium in mechanochemical reactions, the development of modified mechanochemical methods, such as liquid-assisted grinding (LAG) and ion- and liquid-assisted grinding (ILAG), the development of catalytic approaches to conduct solid-state synthesis of covalent bonds and the use of mechanochemical methods to screen for new solid forms and patterns of molecular recognition of pharmaceuticals and steroids.

 

References:

1 A. M. Belenguer, T. Friščić, G. M. Day, J. K. M. Sanders Chem. Sci. 2011, 2, 696.

2 T. Friščić J. Mat. Chem. 2010, 20, 7599.

3 T. Friščić, R. W. Lancaster, L. Fábián, P. Karamertzanis Proc. Natl. Acad. Sci. USA 2010, 107, 13216.