- V. Paar (Univ. Zagreb) - Quantitative tissue
carcinoembryonic antigen (T CEA) assay as a screening test for severe
dysplasia in colorectal adenomas
- Accession Number
- 238TM-0002
- Document Delivery
- 238TM: Document Delivery available
- Authors
- Rosandic
M. Skegro
M. Paar
V. Paar
D. Scukanec-Spoljar
M. Juricic
M. Vucelic
B. Pulanic
R. Rustemovic
N. Ostojic
R. Ljubojevic
N.
- Title
- Quantitative tissue carcinoembryonic antigen (T CEA) assay as a screening
test for severe dysplasia in colorectal adenomas
- Source
- Acta Medica Austriaca. 26(3):89-92, 1999.
- Abbreviated Source
- Acta Med. Austriaca. 26(3):89-92, 1999.
- Copyright Publisher
- BLACKWELL WISSENSCHAFTS-VERLAG GMBH, KURFURSTENDAMM 57, D-10707 BERLIN,
GERMANY. URL: http://www.blackwis.com
- ISSN
- 0303-8173
- Author Keywords
- Carcinoembryonic
antigen (cea). Relationship
between tissue and serum concentrations. Colorectal
adenomas. Dysplasia.
- KeyWords Plus
- Large-bowel.
Polyps.
Serum.
Colon.
- Abstract
- Relationship between the serum (S CEA) and the tissue (T CEA)
carcinoembryonic antigen concentrations with regard to the degree of
dysplasia in colorectal adenomas was investigated. Our study included 56
single or multiple colorectal adenomas in 46 patients. The measurements of T
CEA concentrations were performed using the quantitative CEA-EIA method (Abbott)
modified for wet tissue, obtained from heads of the adenomas. As a control
point the mucosa near adenoma and the rectal mucosa were used. Our results
suggest that the T CEA concentrations from the head of the adenoma
demonstrate a highly significant difference between mild and severe
dysplasia (P < 0.001), between mild dysplasia and invasive adenocarcinoma
(P < 0.001) and a significant difference between mild and moderate
dysplasia (P < 0.05). On the other hand, the S CEA concentrations
corresponding to these cases showed no such differences. In conclusion, we
suggest the quantitative measurement of T CEA concentrations as a screening
test for severe dysplasia in colorectal adenomas. [References: 14]
- Language
- English
- Publication Type
- Article
- Subset
- Current Contents(R)/Clinical Medicine.
- CC Categories
- General & Internal Medicine in Current Contents(R)/Clinical Medicine.
- Entry Week
- 1999 week 42
- Reprint Address
- Reprint available from: Rosandic M. Univ Hosp Rebro, Dept Internal Med,
Div Gastroenterol, Kilpaticeva 12, HR-10000 Zagreb, Croatia.
- Institution
- Reprint available from:
Rosandic M
Univ Hosp Rebro, Dept Internal Med, Div Gastroenterol
Kilpaticeva 12
HR-10000 Zagreb
Croatia
Univ Hosp Rebro, Dept Internal Med, Div Gastroenterol
HR-10000 Zagreb
Croatia
Univ Hosp Rebro, Dept Surg
HR-10000 Zagreb
Croatia
Univ Hosp Rebro, Dept Pathol
HR-10000 Zagreb
Croatia
Univ Hosp Rebro, Dept Gynecol
HR-10000 Zagreb
Croatia
Univ Hosp Rebro, Inst Clin Lab Diagnost
HR-10000 Zagreb
Croatia
Univ Zagreb, Fac Sci
Zagreb 41000
Croatia