V. Paar (Univ. Zagreb) - PROGNOSTIC AND THERAPEUTIC SCORE FOR COLORECTAL ADENOMAS AND THE ROLE OF SERUM AND TISSUE CARCINOEMBRYONIC ANTIGEN

 

Accession Number

ZL649-0009

Document Delivery

The Genuine Article Number: ZL649

Authors

Rosandic M. Paar V.

Reprint Address

Rosandic M

Title

PROGNOSTIC AND THERAPEUTIC SCORE FOR COLORECTAL ADENOMAS AND THE ROLE OF SERUM AND TISSUE CARCINOEMBRYONIC ANTIGEN

Source

European Journal of Gastroenterology & Hepatology. 10(5):405-409, 1998 May.

ISSN

0954-691X

Author Keywords

Colorectal adenomas. Colorectal adenoma score. Dysplasia. Serum carcinoembryonic antigen. Tissue carcinoembryonic antigen.

KeyWords Plus

Polyps. Carcinoma. Cancer.

Abstract

Objective To study the tissue carcinoembryonic antigen (TCEA) concentrations with regard to multiplicity, diameter, pathohistological finding, degree of dysplasia and serum CEA (SCEA) concentrations.

Methods Our study included 46 patients with single or multiple adenomas, For 56 adenomas TCEA concentrations were measured in addition to standard determinations of multiplicity, diameter, pathohistology, degree of dysplasia and SOFA. The measurements of TCEA concentrations were performed using the CEA-EIA method (Abbott) modified for wet tissue obtained from the head of the adenoma (TCEA-A), margin of resection at the neck or base of the adenoma (TCEA-B), mucosa near the adenoma (TCEA-C) and rectal mucosa (TCEA-D), The Mann-Whitney test and M estimates were used to differentiate CEA distribution between various classes of adenomas within each characterization.

Results TCEA concentrations from the head of the adenoma (TCEA-A) demonstrated highly significant difference between mild and severe dysplasia (P = 0,0003), between mild dysplasia and invasive adenocarcinoma (P = 0.001) and significant difference between mild and moderate dysplasia (P = 0,04), There was a statistically significant difference in TCEA-A also between tubular and villous adenomas (P = 0,04), On the other hand, no significant correlations with regard to multiplicity, diameter and pathohistological features were found,

Conclusion These results suggest that there is a highly significant difference between the tissue CEA concentration from the head of the adenoma (TCEA-A) in the presence or absence of severe dysplasia, Furthermore, combining a number of pathological variables together with TCEA and routine SOFA, a new score was proposed to be used as a guide to the frequency of follow-up colonoscopy following polypectomy. (C) 1998 Lippincott-Raven Publishers. [References: 18]

Language

English

Publication Type

Article

CC Categories

Gastroenterology and hepatology.

Subset

Current Contents/Clinical Medicine

Institution

Reprint available from:
Rosandic M
UNIV HOSP REBRO
DEPT INTERNAL MED
DIV GASTROENTEROL
KISPATICEVA 12
ZAGREB 10000
CROATIA